Nicotinamide for skin cancer chemoprevention

Nicotinamide for Skin-Cancer Chemoprevention.

Nicotinamide (vitamin B3 ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelan...

Promising agents for chemoprevention of skin cancer

185 UPDATES AND DEVELOPMENTS IN ONCOLOGY Skin cancer presents a significant public health problem because of its increasing incidence in the United States, Australia, Northern Europe, and other temperate climates around the world. Yet skin cancer (with the exception of melanoma) gets little press in oncology as compared with other malignancies, presumably because of its relatively low mortality...

Chemoprevention of human skin cancer.

The incidence of skin cancer has been rising in recent years with significant effects on public health. Primary prevention has proven inadequate in impacting the incidence of skin cancer, thus stimulating the development of chemopreventive strategies. The majority of skin cancer chemoprevention studies focus on occurrence of new nonmelanoma skin cancers (NMSC) in individuals with a previous NMS...

Chemoprevention of Skin Cancer with Dietary Phytochemicals

Chemoprevention of ultraviolet radiation-induced skin cancer.

The use of chemical and physical sunscreening agents has increased dramatically during the last two to three decades as an effective means of preventing sunbum. The use of high sunprotection factor sunscreens has also been widely promoted for the prevention of skin cancer, including melanoma. Whereas sunscreens are undoubtedly effective in preventing sunbum, their efficacy in preventing skin ca...